Mouse Ntrk2 Antibody

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ProSci
Product Code: PSI-57-360
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-57-360-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of lysate from mouse NIH/3T3 cell line, using Mouse Ntrk2 Antibody at 1:1000 at each lane.
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Mouse Ntrk2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis of lysate from mouse NIH/3T3 cell line, using Mouse Ntrk2 Antibody at 1:1000 at each lane.
Mouse Ntrk2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

Documents

Further Information

Additional Names:
BDNF/NT-3 growth factors receptor, GP145-TrkB/GP95-TrkB, Trk-B, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Ntrk2, Trkb
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Background References:
  • Xu, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):19126-19131(2010)
  • Lobo, M.K., et al. Science 330(6002):385-390(2010)
  • Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)
  • Nikoletopoulou, V., et al. Nature 467(7311):59-63(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Mouse Ntrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the Central region of mouse Ntrk2.
NCBI Gene ID #:
18212
NCBI Official Name:
BDNF/NT-3 growth factors receptor
NCBI Official Symbol:
Ntrk2
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
Protein Accession #:
P15209
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Neuroscience,Signal Transduction
Swissprot #:
P15209
User NOte:
Optimal dilutions for each application to be determined by the researcher.