PPARA Antibody
| Code | Size | Price |
|---|
| PSI-56-728-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Peroxisome proliferators include hypolipidemic drugs,
herbicides, leukotriene antagonists, and plasticizers; this term
arises because they induce an increase in the size and number of
peroxisomes. Peroxisomes are subcellular organelles found in plants
and animals that contain enzymes for respiration and for
cholesterol and lipid metabolism. The action of peroxisome
proliferators is thought to be mediated via specific receptors,
called PPARs, which belong to the steroid hormone receptor
superfamily. PPARs affect the expression of target genes involved
in cell proliferation, cell differentiation and in immune and
inflammation responses. Three closely related subtypes (alpha,
beta/delta, and gamma) have been identified. This gene encodes the
subtype PPAR-alpha, which is a nuclear transcription factor.
Multiple alternatively spliced transcript variants have been
described for this gene, although the full-length nature of only
two has been determined.
Background References:
- Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
- Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Eynon, N., et al. Mitochondrion (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat, Xenopus
Immunogen:
This PPARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-181 amino acids from the Central region of human PPARA.
NCBI Gene ID #:
5465
NCBI Official Name:
Peroxisome proliferator-activated receptor alpha
NCBI Official Symbol:
PPARA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
Q07869
Protein GI Number:
3041727
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity
Swissprot #:
Q07869
User NOte:
Optimal dilutions for each application to be determined by the researcher.