Mouse Ptk2 Antibody
| Code | Size | Price |
|---|
| PSI-57-748-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein-tyrosine kinase 2, p125FAK, pp125FAK, Ptk2, Fadk, Fak, Fak1, Kiaa4203
Application Note:
For WB starting dilution is: 1:1000
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Background References:
- Enciso, J.M., et al. Dev. Dyn. 239(10):2570-2583(2010)
- Beverdam, A., et al. Dev. Dyn. 239(10):2735-2741(2010)
- Ma, Y., et al. FEBS Lett. 584(18):3949-3954(2010)
- Beinke, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16234-16239(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Ptk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-453 amino acids from the Central region of mouse Ptk2.
NCBI Gene ID #:
14083
NCBI Official Name:
Focal adhesion kinase 1
NCBI Official Symbol:
Ptk2
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
124 kDa
Protein Accession #:
P34152
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P34152
User NOte:
Optimal dilutions for each application to be determined by the researcher.