RASAL1 Antibody
| Code | Size | Price |
|---|
| PSI-56-440-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
RasGAP-activating-like protein 1, RASAL1, RASAL
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is member of the GAP1
family of GTPase-activating proteins. These proteins stimulate the
GTPase activity of normal RAS p21 but not its oncogenic
counterpart. Acting as a suppressor of RAS function, the protein
enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing
control of cellular proliferation and differentiation. This
particular family member contains domains which are characteristic
of the GAP1 subfamily of RasGAP proteins but, in contrast to the
other GAP1 family members, this protein is strongly and selectively
expressed in endocrine tissues. Alternatively spliced transcript
variants that encode different isoforms have been described
Background References:
- Ohta, M., et al. Gastroenterology 136(1):206-216(2009)
- Jin, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(30):12353-12358(2007)
- Liu, Q., et al. J. Cell Biol. 170(2):183-190(2005)
- Schmitt, J.M., et al. J. Biol. Chem. 277(45):43024-43032(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.
NCBI Gene ID #:
8437
NCBI Official Name:
RasGAP-activating-like protein 1
NCBI Official Symbol:
RASAL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
O95294
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
O95294
User NOte:
Optimal dilutions for each application to be determined by the researcher.