UBR1 Antibody
| Code | Size | Price |
|---|
| PSI-60-918-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1
Application Note:
For WB starting dilution is: 1:1000
Background:
The N-end rule pathway is one proteolytic pathway of the
ubiquitin system. The recognition component of this pathway,
encoded by this gene, binds to a destabilizing N-terminal residue
of a substrate protein and participates in the formation of a
substrate-linked multiubiquitin chain. This leads to the eventual
degradation of the substrate protein. The protein described in this
record has a RING-type zinc finger and a UBR-type zinc finger.
Mutations in this gene have been associated with Johanson-Blizzard
syndrome.
Background References:
- Elting, M., et al. Am. J. Med. Genet.146A (23), 3058-3061 (2008) :
- Alkhouri, N., et al. World J. Gastroenterol. 14(44):6863-6866(2008)
- Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :
- Schmidt, R.L., et al. Cancer Res. 67(24):11798-11810(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
NCBI Gene ID #:
197131
NCBI Official Name:
E3 ubiquitin-protein ligase UBR1
NCBI Official Symbol:
UBR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
200 kDa
Protein Accession #:
Q8IWV7
Protein GI Number:
73622071
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q8IWV7
User NOte:
Optimal dilutions for each application to be determined by the researcher.