MARCH1 Antibody
| Code | Size | Price |
|---|
| PSI-57-661-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
E3 ubiquitin-protein ligase MARCH1, 632-, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171, MARCH1, RNF171
Application Note:
For WB starting dilution is: 1:1000
Background:
MARCH1 is a member of the MARCH family of membrane-bound
E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin
(see MIM 191339) to target lysines in substrate proteins, thereby
signaling their vesicular transport between membrane compartments.
MARCH1 downregulates the surface expression of major
histocompatibility complex (MHC) class II molecules (see MIM
142880) and other glycoproteins by directing them to the late
endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed
14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et
al., 2008 [PubMed 18305173]).
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Thibodeau, J., et al. Eur. J. Immunol. 38(5):1225-1230(2008)
- De Gassart, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3491-3496(2008)
- Bartee, E., et al. J. Virol. 78(3):1109-1120(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human MARCH1.
NCBI Gene ID #:
55016
NCBI Official Name:
E3 ubiquitin-protein ligase MARCH1
NCBI Official Symbol:
Mar-01
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
Protein Accession #:
Q8TCQ1
Protein GI Number:
74762613
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Immunology
Swissprot #:
Q8TCQ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.