CCNH Antibody
| Code | Size | Price |
|---|
| PSI-55-706-400ul | 400ul | £626.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cyclin-H, MO15-associated protein, p34, p37, CCNH
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene belongs to the highly
conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle.
Cyclins function as regulators of CDK kinases. Different cyclins
exhibit distinct expression and degradation patterns which
contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with CDK7 kinase and ring finger protein
MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2
kinases, thus functions as a CDK-activating kinase (CAK). This
cyclin and its kinase partner are components of TFIIH, as well as
RNA polymerase II protein complexes. They participate in two
different transcriptional regulation processes, suggesting an
important link between basal transcription control and the cell
cycle machinery. A pseudogene of this gene is found on chromosome
4. Alternate splicing results in multiple transcript variants.
Background References:
- Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
- Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
- Young, R.P., et al. Postgrad Med85(1008):515-524(2009)
- Kweekel, D.M., et al. Br. J. Cancer 101(2):357-362(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Immunogen:
This CCNH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CCNH.
NCBI Gene ID #:
902
NCBI Official Name:
Cyclin-H
NCBI Official Symbol:
CCNH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
P51946
Protein GI Number:
1706232
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Immunology
Swissprot #:
P51946
User NOte:
Optimal dilutions for each application to be determined by the researcher.