DCC Antibody
Code | Size | Price |
---|
PSI-56-355-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Images
Documents
Further Information
Additional Names:
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a netrin 1 receptor. The transmembrane
protein is a member of the immunoglobulin superfamily of cell
adhesion molecules, and mediates axon guidance of neuronal growth
cones towards sources of netrin 1 ligand. The cytoplasmic tail
interacts with the tyrosine kinases Src and focal adhesion kinase
(FAK, also known as PTK2) to mediate axon attraction. The protein
partially localizes to lipid rafts, and induces apoptosis in the
absence of ligand. The protein functions as a tumor suppressor, and
is frequently mutated or downregulated in colorectal cancer and
esophageal carcinoma.
Background References:
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Srour, M., et al. Science 328 (5978), 592 (2010) :
- Docherty, S.J., et al. BMC Genet. 11, 61 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
NCBI Gene ID #:
1630
NCBI Official Name:
Netrin receptor DCC
NCBI Official Symbol:
DCC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
158 kDa
Protein Accession #:
P43146
Protein GI Number:
296434474
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience
Swissprot #:
P43146
User NOte:
Optimal dilutions for each application to be determined by the researcher.