Mouse Rnasel Antibody
| Code | Size | Price |
|---|
| PSI-59-203-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4
Application Note:
For WB starting dilution is: 1:1000
Background:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).
Background References:
- Ireland, D.D., et al. PLoS Pathog.(10), E1000602 (2009) :
- Andersen, J.B., et al. RNA Biol 6(3):305-315(2009)
- Salehzada, T., et al. PLoS ONE(10), E7563 (2009) :
- Li, X.L., et al. Proc. Natl. Acad. Sci. U.S.A. 105(52):20816-20821(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.
NCBI Gene ID #:
24014
NCBI Official Name:
2-5A-dependent ribonuclease
NCBI Official Symbol:
Rnasel
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
Q05921
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q05921
User NOte:
Optimal dilutions for each application to be determined by the researcher.