Mouse Il12b Antibody
| Code | Size | Price |
|---|
| PSI-60-064-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, Il12b
Application Note:
For WB starting dilution is: 1:1000
Background:
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC (By similarity).
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Background References:
- Kagami, S., et al. J. Immunol. 185(9):5453-5462(2010)
- Wozniak, T.M., et al. Infect. Immun. 78(10):4187-4194(2010)
- Lindsay, R.W., et al. J. Immunol. 185(3):1513-1521(2010)
- Marshall, H.D., et al. J. Immunol. 185(3):1419-1428(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Il12b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-222 amino acids from the Central region of mouse Il12b.
NCBI Gene ID #:
16160
NCBI Official Name:
Interleukin-12 subunit beta
NCBI Official Symbol:
Il12b
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
P43432
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
P43432
User NOte:
Optimal dilutions for each application to be determined by the researcher.