PIK3C2A Antibody
| Code | Size | Price |
|---|
| PSI-56-082-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PI3K-C2-alpha, PtdIns-3-kinase C2 subunit alpha, Phosphoinositide 3-kinase-C2-alpha, PIK3C2A
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene belongs to the
phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic
transformation, cell survival, cell migration, and intracellular
protein trafficking. This protein contains a lipid kinase catalytic
domain as well as a C-terminal C2 domain, a characteristic of class
II PI3-kinases. C2 domains act as calcium-dependent phospholipid
binding motifs that mediate translocation of proteins to membranes,
and may also mediate protein-protein interactions. The PI3-kinase
activity of this protein is not sensitive to nanomolar levels of
the inhibitor wortmanin. This protein was shown to be able to be
activated by insulin and may be involved in integrin-dependent
signaling.
Background References:
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Kostakis, G.C., et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 (5), E53-E58 (2010) :
- Koutros, S., et al. Cancer Res. 70(6):2389-2396(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PIK3C2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1431-1458 amino acids from the C-terminal region of human PIK3C2A.
NCBI Gene ID #:
5286
NCBI Official Name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
NCBI Official Symbol:
PIK3C2A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
191 kDa
Protein Accession #:
O00443
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
O00443
User NOte:
Optimal dilutions for each application to be determined by the researcher.