KCNQ3 Antibody
| Code | Size | Price |
|---|
| PSI-57-914-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv73, KCNQ3
Application Note:
For WB starting dilution is: 1:1000
Background:
The M channel is a slowly activating and deactivating
potassium channel that plays a critical role in the regulation of
neuronal excitability. The M channel is formed by the association
of the protein encoded by this gene and one of two related proteins
encoded by the KCNQ2 and KCNQ5 genes, both integral membrane
proteins. M channel currents are inhibited by M1 muscarinic
acetylcholine receptors and activated by retigabine, a novel
anti-convulsant drug. Defects in this gene are a cause of benign
familial neonatal convulsions type 2 (BFNC2), also known as
epilepsy, benign neonatal type 2 (EBN2).
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This KCNQ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 651-679 amino acids from the C-terminal region of human KCNQ3.
NCBI Gene ID #:
3786
NCBI Official Name:
Potassium voltage-gated channel subfamily KQT member 3
NCBI Official Symbol:
KCNQ3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
O43525
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
O43525
User NOte:
Optimal dilutions for each application to be determined by the researcher.