Mouse Epha2 Antibody
| Code | Size | Price |
|---|
| PSI-57-864-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2
Application Note:
For WB starting dilution is: 1:1000
Background:
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity). Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.
Background References:
- Islam, S., et al. Dig. Dis. Sci. 55(9):2478-2488(2010)
- Kim, J., et al. Mol. Cell. Biol. 30(7):1582-1592(2010)
- Zirzow, S., et al. Dev. Biol. 336(2):145-155(2009)
- Jun, G., et al. PLoS Genet.(7), E1000584 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.
NCBI Gene ID #:
13836
NCBI Official Name:
Ephrin type-A receptor 2
NCBI Official Symbol:
Epha2
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
109 kDa
Protein Accession #:
Q03145
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q03145
User NOte:
Optimal dilutions for each application to be determined by the researcher.