SHANK2 Antibody
| Code | Size | Price |
|---|
| PSI-56-643-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that is a member of the Shank
family of synaptic proteins that may function as molecular
scaffolds in the postsynaptic density (PSD). Shank proteins contain
multiple domains for protein-protein interaction, including ankyrin
repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha
motif domain, and a proline-rich region. This particular family
member contains a PDZ domain, a consensus sequence for cortactin
SH3 domain-binding peptides and a sterile alpha motif. The
alternative splicing demonstrated in Shank genes has been suggested
as a mechanism for regulating the molecular structure of Shank and
the spectrum of Shank-interacting proteins in the PSDs of adult and
developing brain. Two alternative splice variants, encoding
distinct isoforms, are reported. Additional splice variants exist
but their full-length nature has not been determined. [provided by
RefSeq].
Background References:
- Pinto, D., et al. Nature 466(7304):368-372(2010)
- Berkel, S., et al. Nat. Genet. 42(6):489-491(2010)
- Lee, J.S., et al. J. Biol. Chem. 285(11):8104-8113(2010)
- Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.
NCBI Gene ID #:
22941
NCBI Official Name:
SH3 and multiple ankyrin repeat domains protein 2
NCBI Official Symbol:
SHANK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
159 kDa
Protein Accession #:
Q9UPX8
Protein GI Number:
254763402
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q9UPX8
User NOte:
Optimal dilutions for each application to be determined by the researcher.