ITM2B Antibody
| Code | Size | Price |
|---|
| PSI-56-894-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2
Application Note:
For IHC-P starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
For WB starting dilution is: 1:1000
Background:
Amyloid precursor proteins are processed by beta-secretase
and gamma-secretase to produce beta-amyloid peptides which form the
characteristic plaques of Alzheimer disease. This gene encodes a
transmembrane protein which is processed at the C-terminus by furin
or furin-like proteases to produce a small secreted peptide which
inhibits the deposition of beta-amyloid. Mutations which result in
extension of the C-terminal end of the encoded protein, thereby
increasing the size of the secreted peptide, are associated with
two neurogenerative diseases, familial British dementia and
familial Danish dementia.
Background References:
- Peng, S., et al. Biochem. Biophys. Res. Commun. 393(3):356-361(2010)
- Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
- Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
- Tsachaki, M., et al. Biotechnol3(12):1548-1554(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.
NCBI Gene ID #:
9445
NCBI Official Name:
Integral membrane protein 2B
NCBI Official Symbol:
ITM2B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
Q9Y287
Protein GI Number:
12643343
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q9Y287
User NOte:
Optimal dilutions for each application to be determined by the researcher.