RBP3 Antibody
| Code | Size | Price |
|---|
| PSI-59-446-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein, RBP3
Application Note:
For WB starting dilution is: 1:2000
Background:
Interphotoreceptor retinol-binding protein is a large
glycoprotein known to bind retinoids and found primarily in the
interphotoreceptor matrix of the retina between the retinal pigment
epithelium and the photoreceptor cells. It is thought to transport
retinoids between the retinal pigment epithelium and the
photoreceptors, a critical role in the visual process.The human
IRBP gene is approximately 9.5 kbp in length and consists of four
exons separated by three introns. The introns are 1.6-1.9 kbp long.
The gene is transcribed by photoreceptor and retinoblastoma cells
into an approximately 4.3-kilobase mRNA that is translated and
processed into a glycosylated protein of 135,000 Da. The amino acid
sequence of human IRBP can be divided into four contiguous homology
domains with 33-38% identity, suggesting a series of gene
duplication events. In the gene, the boundaries of these domains
are not defined by exon-intron junctions, as might have been
expected. The first three homology domains and part of the fourth
are all encoded by the first large exon, which is 3,180 base pairs
long. The remainder of the fourth domain is encoded in the last
three exons, which are 191, 143, and approximately 740 base pairs
long, respectively.
Background References:
- Garcia-Ramirez, M., et al. Diabetologia 52(12):2633-2641(2009)
- den Hollander, A.I., et al. Invest. Ophthalmol. Vis. Sci. 50(4):1864-1872(2009)
- Jin, M., et al. J. Neurosci. 29(5):1486-1495(2009)
- Descamps, F.J., et al. J. Cell. Mol. Med. 12 (6A), 2449-2456 (2008) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 784-811 amino acids from the Central region of human RBP3.
NCBI Gene ID #:
5949
NCBI Official Name:
Retinol-binding protein 3
NCBI Official Symbol:
RBP3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
135 kDa
Protein Accession #:
P10745
Protein GI Number:
124894
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P10745
User NOte:
Optimal dilutions for each application to be determined by the researcher.