VANGL2 Antibody

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ProSci
Product Code: PSI-60-897
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-60-897-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in mouse brain tissue lysates (35ug/lane).
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Western blot analysis in mouse brain tissue lysates (35ug/lane).

Documents

Further Information

Additional Names:
Vang-like protein 2, Loop-tail protein 1 homolog, Strabismus 1, Van Gogh-like protein 2, VANGL2, KIAA1215, STB1
Application Note:
For WB starting dilution is: 1:1000
Background:
Planar cell polarity (PCP) is the term given to global cell polarization, such as the alignment of mammalian body hair along the anterior-posterior axis or the orientation of steriocilia bundles in the inner ear. VANGL2 is a PCP protein that is involved in the transmission of directional cues to align either individual cells within an epithelial sheet or multicellular clusters, which polarize as a group (Devenport and Fuchs, 2008 [PubMed 18849982]).
Background References:
  • Lei, Y.P., et al. N. Engl. J. Med. 362(23):2232-2235(2010)
  • Yates, L.L., et al. Hum. Mol. Genet. 19(11):2251-2267(2010)
  • Cantrell, V.A., et al. Cancer Lett. 287(1):54-61(2010)
  • Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This VANGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human VANGL2.
NCBI Gene ID #:
57216
NCBI Official Name:
Vang-like protein 2
NCBI Official Symbol:
VANGL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q9ULK5
Protein GI Number:
38258849
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9ULK5
User NOte:
Optimal dilutions for each application to be determined by the researcher.