UNC13B Antibody
| Code | Size | Price |
|---|
| PSI-56-860-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is expressed in the kidney cortical epithelial
cells and is upregulated by hyperglycemia. The encoded protein
shares a high level of similarity to the rat homolog, and contains
3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia
increases the levels of diacylglycerol, which has been shown to
induce apoptosis in cells transfected with this gene and thus
contribute to the renal cell complications of hyperglycemia.
Studies in other species also indicate a role for this protein in
the priming step of synaptic vesicle exocytosis. [provided by
RefSeq].
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Goldenberg, N.M., et al. Am. J. Physiol., Cell Physiol. 297 (4), C1053-C1058 (2009) :
- Dimova, K., et al. Biochemistry 48(25):5908-5921(2009)
- Tregouet, D.A., et al. Diabetes 57(10):2843-2850(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the N-terminal region of human UNC13B.
NCBI Gene ID #:
10497
NCBI Official Name:
Protein unc-13 homolog B
NCBI Official Symbol:
UNC13B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
181 kDa
Protein Accession #:
O14795
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
O14795
User NOte:
Optimal dilutions for each application to be determined by the researcher.