LRP5 Antibody
| Code | Size | Price |
|---|
| PSI-57-888-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a transmembrane low-density lipoprotein
receptor that binds and internalizes ligands in the process of
receptor-mediated endocytosis. This protein also acts as a
co-receptor with Frizzled protein family members for transducing
signals by Wnt proteins and was originally cloned on the basis of
its association with type 1 diabetes mellitus in humans. This
protein plays a key role in skeletal homeostasis and many bone
density related diseases are caused by mutations in this gene.
Mutations in this gene also cause familial exudative
vitreoretinopathy.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)
- Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
- Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This LRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1163-1190 amino acids from the C-terminal region of human LRP5.
NCBI Gene ID #:
4041
NCBI Official Name:
Low-density lipoprotein receptor-related protein 5
NCBI Official Symbol:
LRP5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
179 kDa
Protein Accession #:
O75197
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
O75197
User NOte:
Optimal dilutions for each application to be determined by the researcher.