PTPN1 Antibody
| Code | Size | Price |
|---|
| PSI-60-913-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is the founding member of
the protein tyrosine phosphatase (PTP) family, which was isolated
and identified based on its enzymatic activity and amino acid
sequence. PTPs catalyze the hydrolysis of the phosphate monoesters
specifically on tyrosine residues. Members of the PTP family share
a highly conserved catalytic motif, which is essential for the
catalytic activity. PTPs are known to be signaling molecules that
regulate a variety of cellular processes including cell growth,
differentiation, mitotic cycle, and oncogenic transformation. This
PTP has been shown to act as a negative regulator of insulin
signaling by dephosphorylating the phosphotryosine residues of
insulin receptor kinase. This PTP was also reported to
dephosphorylate epidermal growth factor receptor kinase, as well as
JAK2 and TYK2 kinases, which implicated the role of this PTP in
cell growth control, and cell response to interferon stimulation.
Background References:
- Stuible, M., et al. Trends Cell Biol. 20(11):672-679(2010)
- Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
- Pradhan, S., et al. J. Biol. Chem. 285(38):29059-29068(2010)
- Brasil, A.S., et al. Genet Test Mol Biomarkers 14(3):425-432(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This PTPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human PTPN1.
NCBI Gene ID #:
5770
NCBI Official Name:
Tyrosine-protein phosphatase non-receptor type 1
NCBI Official Symbol:
PTPN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
P18031
Protein GI Number:
131467
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P18031
User NOte:
Optimal dilutions for each application to be determined by the researcher.