DOK7 Antibody
| Code | Size | Price |
|---|
| PSI-57-126-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is essential for
neuromuscular synaptogenesis. The protein functions in aneural
activation of muscle-specific receptor kinase, which is required
for postsynaptic differentiation, and in the subsequent clustering
of the acetylcholine receptor in myotubes. This protein can also
induce autophosphorylation of muscle-specific receptor kinase.
Mutations in this gene are a cause of familial limb-girdle
myasthenia autosomal recessive, which is also known as congenital
myasthenic syndrome type 1B. Alternative splicing results in
multiple transcript variants.
Background References:
- Bergamin, E., et al. Mol. Cell 39(1):100-109(2010)
- Srour, M., et al. Neuromuscul. Disord. 20(7):453-457(2010)
- Maselli, R.A., et al. Hum. Mol. Genet. 19(12):2370-2379(2010)
- Ben Ammar, A., et al. J. Neurol. 257(5):754-766(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.
NCBI Gene ID #:
285489
NCBI Official Name:
Protein Dok-7
NCBI Official Symbol:
DOK7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
Q18PE1
Protein GI Number:
115311705
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q18PE1
User NOte:
Optimal dilutions for each application to be determined by the researcher.