Mouse Tlk1 Antibody
| Code | Size | Price |
|---|
| PSI-59-114-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1
Application Note:
For WB starting dilution is: 1:1000
Background:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
Background References:
- Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :
- Taniwaki, T., et al. Dev. Growth Differ. 47(3):163-172(2005)
- Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :
- Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Human
Immunogen:
This Mouse Tlk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of mouse Tlk1.
NCBI Gene ID #:
228012
NCBI Official Name:
Serine/threonine-protein kinase tousled-like 1
NCBI Official Symbol:
Tlk1
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q8C0V0
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8C0V0
User NOte:
Optimal dilutions for each application to be determined by the researcher.