PDE8B Antibody
| Code | Size | Price |
|---|
| PSI-60-835-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, HsPDE8B, Cell proliferation-inducing gene 22 protein, PDE8B
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a cyclic nucleotide
phosphodiesterase (PDE) that catalyzes the hydrolysis of the second
messenger cAMP. The encoded protein, which does not hydrolyze cGMP,
is resistant to several PDE inhibitors. Defects in this gene are a
cause of autosomal dominant striatal degeneration (ADSD). Several
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Horvath, A., et al. Thyroid 20(4):363-367(2010)
- Rose, J. Phd, et al. Mol. Med. (2010) In press :
- Appenzeller, S., et al. Am. J. Hum. Genet. 86(1):83-87(2010)
- Shields, B.M., et al. J. Clin. Endocrinol. Metab. 94(11):4608-4612(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.
NCBI Gene ID #:
8622
NCBI Official Name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
NCBI Official Symbol:
PDE8B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
99 kDa
Protein Accession #:
O95263
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O95263
User NOte:
Optimal dilutions for each application to be determined by the researcher.