RAP1A Antibody
| Code | Size | Price |
|---|
| PSI-56-753-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1
Application Note:
For WB starting dilution is: 1:1000
Background:
The product of this gene belongs to the family of
RAS-related proteins. These proteins share approximately 50% amino
acid identity with the classical RAS proteins and have numerous
structural features in common. The most striking difference between
RAP proteins and RAS proteins resides in their 61st amino acid:
glutamine in RAS is replaced by threonine in RAP proteins. The
product of this gene counteracts the mitogenic function of RAS
because it can interact with RAS GAPs and RAF in a competitive
manner. Two transcript variants encoding the same protein have been
identified for this gene.
Background References:
- Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)
- Kelly, P., et al. J. Biol. Chem. 285(21):15777-15785(2010)
- Ahmed, S.M., et al. J. Biol. Chem. 285(9):6538-6551(2010)
- Hsu, Y.H., et al. PLoS Genet.(6), E1000977 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rat, Chicken, Zebrafish, Human, Monkey, Xenopus
Immunogen:
This RAP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the C-terminal region of human RAP1A.
NCBI Gene ID #:
5906
NCBI Official Name:
Ras-related protein Rap-1A
NCBI Official Symbol:
RAP1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
P62834
Protein GI Number:
51338607
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P62834
User NOte:
Optimal dilutions for each application to be determined by the researcher.