PSCD2 Antibody
| Code | Size | Price |
|---|
| PSI-56-293-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the PSCD
family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a
central Sec7 domain, and a C-terminal pleckstrin homology (PH)
domain. The coiled-coil motif is involved in homodimerization, the
Sec7 domain contains guanine-nucleotide exchange protein (GEP)
activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of
this family appear to mediate the regulation of protein sorting and
membrane trafficking. The encoded protein exhibits GEP activity in
vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)
- Torii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)
- White, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)
- Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Immunogen:
This PSCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human PSCD2.
NCBI Gene ID #:
9266
NCBI Official Name:
Cytohesin-2
NCBI Official Symbol:
CYTH2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q99418
Protein GI Number:
13124707
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q99418
User NOte:
Optimal dilutions for each application to be determined by the researcher.