ACTN2 Antibody
| Code | Size | Price |
|---|
| PSI-58-122-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2
Application Note:
For WB starting dilution is: 1:1000
Background:
Alpha actinins belong to the spectrin gene superfamily
which represents a diverse group of cytoskeletal proteins,
including the alpha and beta spectrins and dystrophins. Alpha
actinin is an actin-binding protein with multiple roles in
different cell types. In nonmuscle cells, the cytoskeletal isoform
is found along microfilament bundles and adherens-type junctions,
where it is involved in binding actin to the membrane. In contrast,
skeletal, cardiac, and smooth muscle isoforms are localized to the
Z-disc and analogous dense bodies, where they help anchor the
myofibrillar actin filaments. This gene encodes a muscle-specific,
alpha actinin isoform that is expressed in both skeletal and
cardiac muscles.
Background References:
- Saus, E., et al.Psychiatr Res 44(14):971-978(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This ACTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-779 amino acids from the C-terminal region of human ACTN2.
NCBI Gene ID #:
88
NCBI Official Name:
Alpha-actinin-2
NCBI Official Symbol:
ACTN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Protein Accession #:
P35609
Protein GI Number:
543742
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P35609
User NOte:
Optimal dilutions for each application to be determined by the researcher.