Mouse Derl2 Antibody
| Code | Size | Price |
|---|
| PSI-60-461-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa, Derl2, Der2, Flana
Application Note:
For WB starting dilution is: 1:1000
Background:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).
Background References:
- Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :
- Oda, Y., et al. J. Cell Biol. 172(3):383-393(2006)
- Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102(40):14296-14301(2005)
- Kaput, J., et al. Physiol. Genomics 18(3):316-324(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.
NCBI Gene ID #:
116891
NCBI Official Name:
Derlin-2
NCBI Official Symbol:
Derl2
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
Q8BNI4
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8BNI4
User NOte:
Optimal dilutions for each application to be determined by the researcher.