ASXL1 Antibody
| Code | Size | Price |
|---|
| PSI-55-656-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1, ASXL1, KIAA0978
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
This gene is similar to the Drosophila additional sex
combs gene, which encodes a chromatin-binding protein required for
normal determination of segment identity in the developing embryo.
The protein is a member of the Polycomb group of proteins, which
are necessary for the maintenance of stable repression of homeotic
and other loci. The protein is thought to disrupt chromatin in
localized areas, enhancing transcription of certain genes while
repressing the transcription of other genes. The protein encoded by
this gene functions as a ligand-dependent co-activator for retinoic
acid receptor in cooperation with nuclear receptor coactivator 1.
Mutations in this gene are associated with myelodysplastic
syndromes and chronic myelomonocytic leukemia. Alternative splicing
results in multiple transcript variants.
Background References:
- Abdel-Wahab, O., et al. Leukemia 24(9):1656-1657(2010)
- Szpurka, H., et al. Leuk. Res. 34(8):969-973(2010)
- Sugimoto, Y., et al. Br. J. Haematol. 150(1):83-87(2010)
- Boultwood, J., et al. Leukemia 24(6):1139-1145(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ASXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1.
NCBI Gene ID #:
171023
NCBI Official Name:
Putative Polycomb group protein ASXL1
NCBI Official Symbol:
ASXL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
165 kDa
Protein Accession #:
Q8IXJ9
Protein GI Number:
317373477
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8IXJ9
User NOte:
Optimal dilutions for each application to be determined by the researcher.