MDS1 Antibody
| Code | Size | Price |
|---|
| PSI-58-431-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
MDS1 and EVI1 complex locus protein MDS1, Myelodysplasia syndrome 1 protein, Myelodysplasia syndrome-associated protein 1, MECOM, MDS1
Application Note:
For WB starting dilution is: 1:1000
Background:
MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.
Background References:
- Gomez-Benito, M., et al. Br. J. Cancer 103(8):1292-1296(2010)
- Meyer, T.E., et al. PLoS Genet.(8) (2010) :
- Goyama, S., et al. Int. J. Hematol. 91(5):753-757(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the Central region of human MDS1.
NCBI Gene ID #:
2122
NCBI Official Name:
MDS1 and EVI1 complex locus protein MDS1
NCBI Official Symbol:
MECOM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Protein Accession #:
Q13465
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q13465
User NOte:
Optimal dilutions for each application to be determined by the researcher.