Mouse Slc5a8 Antibody
| Code | Size | Price |
|---|
| PSI-60-717-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8, Slc5a8 {ECO:0000312|MGI:MGI:2384916}
Application Note:
For WB starting dilution is: 1:1000
Background:
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
Background References:
- Borthakur, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G928-G934 (2010) :
- Singh, N., et al. J. Biol. Chem. 285(36):27601-27608(2010)
- Becker, H.M., et al. Am. J. Physiol. Renal Physiol. 299 (1), F141-F154 (2010) :
- Miyauchi, S., et al. Biochim. Biophys. Acta 1798(6):1164-1171(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Mouse Slc5a8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-574 amino acids from the C-terminal region of mouse Slc5a8.
NCBI Gene ID #:
216225
NCBI Official Name:
Sodium-coupled monocarboxylate transporter 1
NCBI Official Symbol:
Slc5a8
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
67 kDa
Protein Accession #:
Q8BYF6
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q8BYF6
User NOte:
Optimal dilutions for each application to be determined by the researcher.