IL-17A (human):Fc (human) (rec.)

Interleukin-17A; Cytotoxic T-lymphocyte-associated Antigen 8; CTLA-8

32160000

<0.06EU/µg purified protein (LAL test; Lonza).

solid

Lyophilized from 0.2µm-filtered solution in 1X PBS.

Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Protein. The extracellular domain of human IL-17A (aa 24-155) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/µg purified protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in 1X PBS. Purity: >90% (SDS-PAGE). Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

~42kDa (SDS-PAGE)

AAH67505.1

Plastic Vial

Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

>90% (SDS-PAGE)

The extracellular domain of human IL-17A (aa 24-155) is fused at the C-terminus to the Fc portion of human IgG1.

HEK 293 cells

Fc

Non-hazardous

Other Proteins

12352202

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.