DAMGO . AcOH
| Code | Size | Price |
|---|
| AG-CP3-0005V-M001 | 1 mg | £51.00 |
Quantity:
| AG-CP3-0005V-M005 | 5 mg | £140.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin; H-Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol . acetate; DAGO; DAMGE; Dagol; RX 783006
Appearance:
White powder.
CAS:
100929-53-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36);1H3,(H,3,4)/t17-,21+,22+;/m1./s1
InChiKey:
XZZYKCKUDLGXJA-NJUGUJQKSA-N
Long Description:
Chemical. CAS: 100929-53-1. Formula: C26H35N5O6 . C2H4O2. MW: 513.6 . 60.1. Synthetic. Potent, selective agonist of µ-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food intake of rats.
MDL:
MFCD00133215
Molecular Formula:
C26H35N5O6 . C2H4O2
Molecular Weight:
513.6 . 60.1
Package Type:
Plastic Vial
Product Description:
Potent, selective agonist of µ-opioid receptor [1]. Antinociceptive [2,3]. Stimulates calcium-activated adenylyl cyclases related cAMP production [4]. Expresses chemokines and chemokine receptors through TGF-beta1 [5]. Increases food intake of rats [6].
Purity:
>98% (HPLC)
SMILES:
O=C(NCCO)[C@@H](N(C(CNC([C@H](NC([C@@H]([NH3+])CC1=CC=C(O)C=C1)=O)C)=O)=O)C)CC2=CC=CC=C2.CC([O-])=O
Solubility Chemicals:
Soluble in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops: T. Onogi, et al.; FEBS Lett. 357, 93 (1995) | Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats: N. Selve, et al.; Brain Res. 735, 177 (1996) | Long-lasting antinociceptive effect of DAMGO chloromethyl ketone in rats: G. Szabo, et al.; Peptides 20, 1321 (1999) | The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway: V. Rubovitch, et al.; Mol. Brain Res. 110, 261 (2003) | DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1: C. Happel, et al.; J. Leukoc. Biol. 83, 956 (2008) | Enkephalin surges in dorsal neostriatum as a signal eat: A.G. DiFeliceantonio, et al.; Curr. Biol. 22, 1918 (2012)