DLL1 (mouse):Fc (human) (rec.)
| Code | Size | Price |
|---|
| AG-40A-0148Y-C010 | 10 ug | £130.00 |
Quantity:
| AG-40A-0148Y-C050 | 50 ug | £260.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Delta-like Protein 1; Delta 1
Biological Activity:
Inhibits adipogenesis of 3T3L-1 cells. Induces Hes-1 in 3T3L-1 cells.
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Extracellular domain of mouse DLL1 (aa 18-545) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin: <0.1EU/µg. Lyophilized. Contains PBS. The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor.
Molecular Weight:
~100kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q61483
Package Type:
Plastic Vial
Product Description:
The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor.
Purity:
>90% (SDS-PAGE)
Sequence:
Extracellular domain of mouse DLL1 (aa 18-545) is fused at the C-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Interacts with Notch receptors.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Flt-1 (Vascular Endothelial Growth Factor Receptor-1) Is Essential for the Vascular Endothelial Growth Factor-Notch Feedback Loop During Angiogenesis: J.C. Chappell, et al.; Arterioscler. Thromb. Vasc. Biol. 33, 1952 (2013) | Mimicking The Stem Cell Niche In Diseased Muscle With A Notch Activator-conjugated 3d-construct: X. Mu, et al.; ORS Annual Meeting Transactions Presentation (2014) | Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors: M. Weiss-Gayet, et al.; PLoS One 11, e0153860 (2016) | Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression: Z. Martinez-Lozada & M.B. Robinson; Neurochem. Int. ahead of print (2020)
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