CX-5461
| Code | Size | Price |
|---|
| SYN-3031-M001 | 1 mg | £115.00 |
Quantity:
| SYN-3031-M005 | 5 mg | £197.00 |
Quantity:
| SYN-3031-M010 | 10 mg | £303.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
CX5461
Appearance:
Solid.
CAS:
1138549-36-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C27H27N7O2S/c1-17-14-29-18(15-28-17)16-30-26(36)23-24(35)19-8-9-22(33-11-5-10-32(2)12-13-33)31-25(19)34-20-6-3-4-7-21(20)37-27(23)34/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3,(H,30,36)
InChiKey:
XGPBJCHFROADCK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1138549-36-6. Formula: C27H27N7O2S. MW: 513.6. Synthetic. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Molecular Formula:
C27H27N7O2S
Molecular Weight:
513.6
Package Type:
Vial
Product Description:
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Purity:
>95%
Solubility Chemicals:
Slightly soluble (<1mg/ml) in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 602 (2012)
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