Glycoprotein / GP (virus) Recombinant Protein
| Code | Size | Price |
|---|
| PSI-97-053-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Cytomegalovirus (CMV)
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Cytomegalovirus Glycoprotein
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. CMV Virus Envelope Glycoportein B (CMV-GB) can be cleaved into glycoprotein GP55. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. CMV-GB may be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Furthermore, CMV-GB can interact with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also, CMV-GB participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Background References:
- Wang X., et al., 2002, Nature 424:456-461.
- Feire A.L., et al., 2009, J. Virol. 84:10026-10037.
- Halary F., et al., 2001, Immunity 17:653-664.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
223014
NCBI Official Name:
glycoprotein B precursor
NCBI Official Symbol:
Glycoprotein / GP (virus)
NCBI Organism:
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
Physical State:
Lyophilized
Predicted Molecular Weight:
104 kDa
Protein Accession #:
AAA45920.1
Purity:
>85% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P13201