TIM-3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-813-0.1mg | 0.1mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Background References:
- Monney, L. et al., 2002, Nature, 415:536-541.
- Sabatos, CA. et al., 2003, Nat. Immunol., 4:1102-1110.
- Anderson, AC. et al., 2006, Curr. Opin. Immunol., 18:665-669.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus TIM-3, Fc Tag at 2 ug/mL (100 uL/well) can bind Anti-TIM3 Mab, Human IgG4 with a linear range of 0.5-4 ng/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
15593
NCBI Official Name:
hypothetical protein EGM_15593
NCBI Official Symbol:
TIM-3
NCBI Organism:
Macaca fascicularis?
Physical State:
Lyophilized
Predicted Molecular Weight:
45.8 kDa
Protein Accession #:
EHH54703.1
Purity:
>85% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
G7P6Q7