IL-4 R alpha Recombinant Protein

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ProSci
Product Code: PSI-96-797
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-797-0.05mg0.05mg£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species:
  • Cynomolgus Monkey
  • Rhesus Macaque
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
IL4R,CD124,IL4RA
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Ralpha (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin?4?Receptor (IL4R) also known as CD124, IL4Ralpha and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
Background References:
  • Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 : 54?9.
  • Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11): 6382?7.
  • Hage T., et al., 1999, Cell 97 (2): 271?81.
  • Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Official Symbol:
IL-4 R alpha
NCBI Organism:
Macaca fascicularis?
Physical State:
Lyophilized
Predicted Molecular Weight:
50.4 kDa
Protein Accession #:
G7Q0S7
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
G7Q0S7