LILRB2 Recombinant Protein

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ProSci
Product Code: PSI-96-915
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-915-0.1mg0.1mg£626.00
Quantity:
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Overview

Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
LILRB2,ILT4,LIR2,MIR10,CD85d
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Background References:
  • Borges L., et al., 1997, J. Immunol. 159:5192-5196.
  • Fanger N.A., et al., 1998, Eur. J. Immunol. 28:3423-3434.
  • Shiroishi M., et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPTL7, His Tag at 5 ug/mL (100 uL/well) can bind Human LILRB2, Fc Tag with a linear range of 0.031-2 ug/mL (Routinely tested).
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
10288
NCBI Official Name:
Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
NCBI Official Symbol:
LILRB2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
74.4 kDa
Protein Accession #:
AAH36827
Purity:
>85% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8N423