HVEM Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-886-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFbeta (lymphotoxin alpha) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTbetaR, the receptor for lymphotoxin alphabeta heterotrimer. The role of the HVEM LIGHT /LTbeta receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
Background References:
- Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.
- Mauri, D.N. et al., 1998, Immunity 8:21.
- Montgomery, R.I. et al., 1996, Cell 87:427.
- Cheung,T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human HVEM, His Tag at 0.5 ug/mL (100 uL/well) can bind Human BTLA, Fc Tag with a linear range of 0.078-2.5 ug/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
8764
NCBI Official Name:
tumor necrosis factor receptor superfamily member 14 isoform 1 precursor
NCBI Official Symbol:
HVEM
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
19.2 kDa
Protein Accession #:
NP_003811
Purity:
>90% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
NP_003811.2