Nectin-2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-928-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD112,Nectin-2,PVRL2
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Background References:
- Martinez W.M., et al., 2001, J. Virol. 75:11185-11195.
- Yu X., et al., 2009, Nat. Immunol. 10:48-57.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human CD112, Fc Tag at 10 ug/mL (100 uL/well) can bind Biotinylated Human TIGIT, His Tag with a linear range of 0.6-5 ug/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
5819
NCBI Official Name:
Poliovirus receptor-related 2 (herpesvirus entry mediator B)
NCBI Official Symbol:
Nectin-2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
62.2 kDa
Protein Accession #:
AAH03091
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
NP_002847.1