DNAM-1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-864-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
DNAM1,CD226,PTA1
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Background References:
- Shibuya A., et al.,1995, Immunity 4:573-581.
- Tahara-Hanaoka S., et al .,2003, Int. Immunol. 16:533-538.
- Pende D., et al.,2004, Mol. Immunol. 42:463-469.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human DNAM-1, Fc Tag at 10 ug/mL (100 ul/well),can bind Human Nectin-2, His Tag with a linear range of 0.08-1.25 ug/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
10666
NCBI Official Name:
CD226 antigen isoform a precursor
NCBI Official Symbol:
DNAM-1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
52.6 kDa
Protein Accession #:
NP_006557
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q15762-1