IGFBP-4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-890-0.05mg | 0.05mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IGFBP4,IBP-4
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
Background References:
- Tagliabracci V.S., et al., 2015, Cell 161:1619-1632.
- Culouscou J.M., et al.,1991, Cancer Res. 51:2813-2819.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP-4, His Tag at 2 ug/mL (100 ul/well),can bind Human IGF-I, Fc Tag with a linear range of 4-30 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3487
NCBI Official Name:
Insulin-like growth factor binding protein 4
NCBI Official Symbol:
IGFBP-4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
27.9 kDa
Protein Accession #:
AAH16041
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
NP_001543.2