PCSK9 Recombinant Protein

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ProSci
Product Code: PSI-96-935
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-935-0.05mg0.05mg£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Background References:
  • Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928?33.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
  • Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454?9.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human LDL R, His Tag at 10 ug/mL (100 uL/well) can bind Human PCSK9 (R194A), His Tag with a linear range of 0.1-2 ug/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
255738
NCBI Official Name:
proprotein convertase subtilisin/kexin type 9
NCBI Official Symbol:
PCSK9
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
71.8 kDa
Protein Accession #:
AAI166619.1
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8NBP7-1