Betacellulin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-830-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
betacellulin,BTC
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic beta-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.
Background References:
- Watanabe T., et al., 1994, J. Biol. Chem. 269:9966-9973.
- Seno M., et al., 1996, Growth Factors 13:181-191.
- Bermingham Y., et al., 1996, Oncogene 12:345-353.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
685
NCBI Official Name:
BTC protein
NCBI Official Symbol:
Betacellulin
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
36.5 kDa
Protein Accession #:
AAH11618
Purity:
>92% as determined by reduced SDS-PAGE.
Less than 1.0 EU per ug by the LAL method.
Less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P35070