Her2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-884-0.025mg | 0.025mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Human Epidermal growth factor Receptor 2 (HER2),also called ERBB2, HER-2,HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation.
Background References:
- Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067. (2) Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201. (3) Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37. (4) Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.
- Hellyer, N.J. et. al., 2001, J. Biol. Chem. 276:42153.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
2064
NCBI Official Name:
HER2 receptor
NCBI Official Symbol:
Her2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
74.5 kDa
Protein Accession #:
AAA75493
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P04626