M-CSF R Recombinant Protein
| Code | Size | Price |
|---|
| PSI-97-015-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Background References:
- Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4): 1377?80.
- Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442?51.
- Tamimi, R. M., 2008, Cancer Research 68 (1): 18?21.
- Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312?6.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Mouse M-CSF Protein at 2 ug/mL (100 uL/well) can bind Mouse M-CSF R, Fc Tag with a linear range of 0.3-12.8 ng/mL (Routinely tested).
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
12978
NCBI Official Name:
macrophage colony-stimulating factor 1 receptor precursor
NCBI Official Symbol:
M-CSF R
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
81.8 kDa
Protein Accession #:
NP_001032948
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 0.1 EU per ug by the LAL method.
Endotoxin level is less than 0.1 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P09581