PD-L1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-97-020-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Background References:
- Dong H., et al., 1999, Nat. Med. 5:1365-1369.
- Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
- Nishimura H., et al., 2001, Trends?in?Immunology?22:265.?
Buffer:
PBS, pH7.4
Fusion Tag:
mouse IgG2a Fc tag
NCBI Gene ID #:
60533
NCBI Official Name:
Programmed cell death 1 ligand 1
NCBI Official Symbol:
PD-L1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
51.8 kDa
Protein Accession #:
NP_068693
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 0.1 EU per ug by the LAL method.
Endotoxin level is less than 0.1 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
N/A