FKBP12 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-873-0.1mg | 0.1mg | £404.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
Background References:
- Siekierka J.J., et al., 1989, J. Biol. Chem. 265:21011-21015.
- Michnick S.W., et al., 1990, Science 252:836-839.
- van Duyne G.D., et al., 1990, Science 252:839-842.
Buffer:
50 mM HEPES, 150 mM NaCl, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
2280
NCBI Official Name:
FK506 binding protein 1A, 12kDa
NCBI Official Symbol:
FKBP12
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
12.8 kDa
Protein Accession #:
AAH05147
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P62942