PSME3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-941-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PSME3,PA28gamma,REG-gamma
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
Background References:
- Miki Y., et al., 1994, Science 266:66-71.
- Realini C., et al., 1997,J. Biol. Chem. 272:25483-25492.
- Zhang Z., et al., 2008, EMBO J. 27:852-864.
Buffer:
50 mM Tris, 150 mM NaCl, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
10197
NCBI Official Name:
proteasome activator subunit 3
NCBI Official Symbol:
PSME3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
30.3 kDa
Protein Accession #:
NP_00578
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P61289