NME1 Recombinant Protein

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ProSci
Product Code: PSI-96-932
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-932-0.1mg0.1mg£524.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

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Further Information

Additional Names:
NME1,NDP kinase A,NDPA,GAAD,NM23-H1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Nucleoside diphosphate kinase A, a member of the NDK family, is also known as NME1, NDP kinase A (NDPA), granzyme A-activated DNase (GAAD), metastasis inhibition factor nm23 (NM23-H1) and tumor metastatic process-associated protein. NME1 plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 is also involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Furthermore, NME1 is required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, NME1 works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Background References:
  • Rosengard A.M., et al., 1989, Nature 342:177-180.
  • Fan Z., et al., 2003, Cell 112:659-672.
  • Min K., et al., 2002, Proteins 46:340-342.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4830
NCBI Official Name:
Non-metastatic cells 1, protein (NM23A)
NCBI Official Symbol:
NME1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
18 kDa
Protein Accession #:
AAH00293
Purity:
>98% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P15531-1